Microbial conversion of milbemycins: 28-hydroxylation of milbemycins by Amycolata autotrophica.
نویسندگان
چکیده
Milbemycins are a family of sixteen-membered macrolides produced by Streptomyces hygroscopicus subsp. aureolacrimosus. They exhibit broad-spectrum insecticidal and acaricidal activity. * ~ 3) In the course of our studies on the microbial conversion of milbemycins, we obtained 13/?hydroxymilbemycins A4, A3, D, 13/Miydroxy-LLF28249a, 28-hydroxymilbemycin D, and 28-hydroxy-LL-F28249a by using Cunninghamella echinu-
منابع مشابه
Microbial conversion of milbemycins: 29-hydroxylation of milbemycins by genus Syncephalastrum.
In previous papers, we reported that milbemycins were converted into 30-hydroxy, 13/Miydroxy, and 13/?,29-dihydroxy derivatives by using Amycolata autotrophica subsp. amethystina ATCC 35204, Cunninghamella echinulata ATCC9244, and Streptomyces cavourensis SANK67386, respectively.4~6) As part of our continuing screening effort for microbial conversion of milbemycins, we observed that Syncephalas...
متن کاملMicrobial conversion of milbemycins: microbial conversion of milbemycins A4 and A3 by Streptomyces libani.
28-hydroxymilbemycins, 1 3/?,30-dihydroxymilbemycins, and others.4~8) On the other hand, Ramos Tomboet al. have reported 13/Miydroxylation and 14, 1 5-epoxidation of milbemycins by Streptomyces violascens ATCC31560.9) During our screening of microbial conversion of milbemycin A4 (la), we observed that an actinomycete, strain SANK65087, newly isolated from soil, converted milbemycin A4 (la) to a...
متن کاملMicrobial conversion of milbemycins: hydroxylation of milbemycin A4 and related compounds by Cunninghamella echinulata ATCC 9244.
Many strains of zygomycetes and actinomycetes were found to convert milbemycin A4 (1a) to 13 beta-hydroxymilbemycin A4 (1b). Among these strains, Cunninghamella echinulata ATCC 9244 had the most efficient 13 beta-hydroxylation ability on milbemycins. In the conversion of milbemycin A3 (2a), 29-hydroxymilbemycin A4 (4a), and 30-hydroxymilbemycin A4 (5a) with this strain, only 13 beta-hydroxylate...
متن کاملMicrobial conversion of milbemycins: 13 beta, 29-dihydroxylation of milbemycins by soil isolate Streptomyces cavourensis.
Milbemycins are a family of sixteen-membered macrolides produced by Streptomyces hygroscopicus subsp. aureolacrimosus. They exhibit broadspectrum insecticidal and acaricidal activity. * ~ 3) In the course of our studies on the microbial conversion of milbemycins, we obtained 13/?hydroxymilbemycins A3 (2b), A4 (lb), and D (3b) from milbemycins A3 (2a), A4 (la), and D (3a), respectively, and 1 3j...
متن کاملMicrobial conversion of milbemycins: oxidation of milbemycin A4 and related compounds at the C-25 ethyl group by Circinella umbellata and Absidia cylindrospora.
Microbial oxidation of milbemycin A4 at the C-25 ethyl group was performed. Milbemycin A4 was converted to 31- and 32-hydroxy derivatives by Circinella umbellata SANK 44272 along with 24- and 30-hydroxy derivatives. Related compounds, 5-ketomilbemycin A4 5-oxime and 13 beta-fluoromilbemycin A4 were similarly converted to the hydroxylated compounds by this microorganism. Absidia cylindrospora SA...
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ورودعنوان ژورنال:
- The Journal of antibiotics
دوره 46 3 شماره
صفحات -
تاریخ انتشار 1993